A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung Cells-Reference-Cited by-同舟云学术

A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung Cells

Published:2022-01-26 Issue:2 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Basu Abhijit¹,Penumutchu Srinivasa²,Nguyen Kien³,Mbonye Uri³,Tolbert Blanton S.²,Karn Jonathan³,Komar Anton A.¹,Mazumder Barsanjit¹^ORCID

Affiliation:

1. Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA

2. Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA

3. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

Specific RNA elements in the genomes of RNA viruses play important roles in host-virus interaction. For SARS-CoV-2, the mechanistic insights on how these RNA elements could sense the signals from the host cell are lacking.

Funder

Nord Family Foundation

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01678-21

Reference51 articles.

1. Coronavirus biology and replication: implications for SARS-CoV-2