Author:
Brownson J M,Mahy B W,Hazleman B L
Abstract
Peripheral blood lymphocytes cultured in the presence of phytohemagglutinin, concanavalin A, or pokeweed mitogen were exposed in vitro to influenza A virus. The synthesis of several virus-specific proteins, including the nucleoprotein, membrane protein, and nonstructural 1 protein were detected, although no infectious virus was produced by the lymphocyte cultures. Evidence was obtained that only a subpopulation of mitogen-transformed cells would support virus protein synthesis. A comparison of the interactions of influenza A virus with lymphocytes from normal individuals and from rheumatoid arthritis patients showed that the same range of virus-specific proteins were made, in similar quantities, regardless of the source of lymphocytes.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference32 articles.
1. Interactions of antibodies, complement components and various cell types in immunity against viruses and pyogenic bacteria;Allison A. C.;Transplant. Rev.,1974
2. Participation of deoxyribonucleic acid in the multiplication of influenza virus;Barry R. D.;Nature (London),1962
3. Antibody to influenza virus matrix protein detects a common antigen on the surface of cells infected with type A influenza viruses;Biddison W. E.;J. Exp. Med.,1977
4. Deoxyribonucleic acid-dependent ribonucleic acid polymerase activity in cells infected with influenza virus;Borland R.;J. Virol.,1968
5. Bosch F. X. A. J. Hay and J. J. Skehel. 1978. RNA and protein synthesis in a permissive and an abortive influenza virus infection p. 465-474. In B. W. J. Mahy and R. D. Barry (ed.) Negative strand viruses and the host cell. Academic Press London.
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献