Decreased Virulence of a Pneumolysin-Deficient Strain of Streptococcus pneumoniae in Murine Meningitis-Reference-Cited by-同舟云学术

Decreased Virulence of a Pneumolysin-Deficient Strain of Streptococcus pneumoniae in Murine Meningitis

Published:2002-11 Issue:11 Volume:70 Page:6504-6508
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Wellmer Andreas¹,Zysk Gregor²,Gerber Joachim¹,Kunst Tammo¹,von Mering Matthias¹,Bunkowski Stefanie¹,Eiffert Helmut³,Nau Roland¹

Affiliation:

1. Departments of Neurology

2. Institute of Medical Microbiology and Virology, University of Düsseldorf, Düsseldorf, Germany

3. Bacteriology, University of Göttingen, Göttingen

Abstract

ABSTRACT Pneumolysin, neuraminidases A and B, and hyaluronidase are virulence factors of Streptococcus pneumoniae that appear to be involved in the pathogenesis of meningitis. In a murine model of meningitis after intracerebral infection using mutants of S. pneumoniae D39, only mice infected with a pneumolysin-deficient strain were healthier at 32 and 36 h, had lower bacterial titers in blood at 36 h, and survived longer than the D39 parent strain. Cerebellar and spleen bacterial titers, meningeal inflammation, and neuronal damage scores remained uninfluenced by the lack of any of the virulence factors.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.11.6504-6508.2002

Reference30 articles.

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