A Uropathogenicity Island Contributes to the Pathogenicity of Escherichia coli Strains That Cause Neonatal Meningitis-Reference-Cited by-同舟云学术

A Uropathogenicity Island Contributes to the Pathogenicity of Escherichia coli Strains That Cause Neonatal Meningitis

Published:2002-10 Issue:10 Volume:70 Page:5865-5869
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Houdouin Véronique¹,Bonacorsi Stéphane¹,Brahimi Naima¹,Clermont Olivier¹,Nassif Xavier²,Bingen Edouard¹

Affiliation:

1. Laboratoire d'Études de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris 7, Hôpital Robert Debré, 75019 Paris

2. INSERM U 570, Faculté de Médecine Necker-Enfants Malades, 75730 Paris cedex 15, France

Abstract

ABSTRACT We report that the archetypal Escherichia coli strain C5 causing neonatal meningitis harbors a pathogenicity island (PAI) designated PAI I C5 that is similar to the PAI II J96 of uropathogenic E. coli J96 inserted in the leuX- tRNA gene. PAI-negative C5 mutants had a lower capacity than C5 to induce high-level bacteremia in a neonatal rat model. However, no change in their resistance to the bactericidal effect of serum and their capacity to cross the blood-brain barrier was observed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.10.5865-5869.2002

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