In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum-Reference-Cited by-同舟云学术

In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum

Published:1994-05 Issue:5 Volume:38 Page:1169-1171
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Basco L K¹,Mitaku S¹,Skaltsounis A L¹,Ravelomanantsoa N¹,Tillequin F¹,Koch M¹,Le Bras J¹

Affiliation:

1. Laboratoire de Parasitologie, Institut de Médecine et d'Epidémiologie Africaines, Hôpital Bichat-Claude Bernard, Paris, France.

Abstract

The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.38.5.1169

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