Rifampin for therapy of experimental pneumococcal meningitis in rabbits-Reference-Cited by-同舟云学术

Rifampin for therapy of experimental pneumococcal meningitis in rabbits

Published:1994-05 Issue:5 Volume:38 Page:1186-1189
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nau R¹,Kaye K¹,Sachdeva M¹,Sande E R¹,Täuber M G¹

Affiliation:

1. Infectious Diseases Laboratory, San Francisco General Hospital, California 94110.

Abstract

Rifampin at a maximally effective dose was less active than ceftriaxone (both drugs at 10 mg/kg of body weight.h) in a rabbit model of pneumococcal meningitis (delta log10 CFU/ml.h, -0.40 +/- 0.13 versus -0.77 +/- 0.18; P < 0.01). The bactericidal activity of rifampin decreased at concentrations in cerebrospinal fluid greater than those that are clinically achievable, and use of rifampin in combination with ofloxacin had no synergistic or additive effect.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.38.5.1186

Reference26 articles.

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