Pharmacodynamic Target Attainment for Cefepime, Meropenem, and Piperacillin-Tazobactam Using a Pharmacokinetic/Pharmacodynamic-Based Dosing Calculator in Critically Ill Patients-Reference-Cited by-同舟云学术

Pharmacodynamic Target Attainment for Cefepime, Meropenem, and Piperacillin-Tazobactam Using a Pharmacokinetic/Pharmacodynamic-Based Dosing Calculator in Critically Ill Patients

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Heil Emily L.¹,Nicolau David P.²,Farkas Andras³⁴,Roberts Jason A.⁵⁶^ORCID,Thom Kerri A.⁷

Affiliation:

1. University of Maryland School of Pharmacy, Baltimore, Maryland, USA

2. Center for Anti-Infective Research, Hartford Hospital, Hartford, Connecticut, USA

3. Optimum Dosing Strategies, Bloomingdale, New Jersey, USA

4. Mount Sinai West Hospital, New York, New York, USA

5. University of Queensland Centre for Clinical Research, Faculty of Medicine and Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia

6. Pharmacy Department and Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia

7. University of Maryland School of Medicine, Baltimore, Maryland, USA

Abstract

This was a prospective study to determine if pharmacokinetic/pharmacodynamic (PK/PD)-based antibiotic dosing software aids in achieving concentration targets in critically ill patients receiving cefepime ( n = 10), meropenem ( n = 20), or piperacillin-tazobactam ( n = 19). Antibiotic calculator doses targeting a >90% probability of target attainment (PTA) differed from package insert doses for 22.4% (11/49) of patients.

Funder

Society of Infectious Diseases Pharmacists

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01008-18

Reference31 articles.

1. WHO. 2012. The evolving threat of antimicrobial resistance: options for action. World Health Organization, Geneva, Switzerland.

2. Antimicrobial susceptibility pattern comparisons among intensive care unit and general ward Gram-negative isolates from the Meropenem Yearly Susceptibility Test Information Collection Program (USA)

3. Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions