In Vitro and In Vivo Activities of 1-Hydroxy-2-Alkyl-4(1 H )Quinolone Derivatives against Toxoplasma gondii-Reference-Cited by-同舟云学术

In Vitro and In Vivo Activities of 1-Hydroxy-2-Alkyl-4(1 H )Quinolone Derivatives against Toxoplasma gondii

Published:2010-01 Issue:1 Volume:54 Page:517-521
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bajohr Lara Liv¹,Ma Ling²,Platte Christian³,Liesenfeld Oliver¹,Tietze Lutz F.²,Groß Uwe³,Bohne Wolfgang³

Affiliation:

1. Institut für Mikrobiologie und Hygiene, Charité Universtätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 27, 12203 Berlin, Germany

2. Institut für Organische und Biomolekulare Chemie, Universität Göttingen, Tammannstr. 2, D-37077 Göttingen, Germany

3. Institut für Medizinische Mikrobiologie, Universitätsmedizin Göttingen, Kreuzbergring 57, D-37075 Göttingen, Germany

Abstract

ABSTRACT 1-Hydroxy-2-dodecyl-4(1 H )quinolone (HDQ) was recently identified as a Toxoplasma gondii inhibitor. We describe here two novel 1-hydroxyquinolones, which displayed 50% inhibitory concentrations 10- and 5-fold lower than that of HDQ. In a mouse model of acute toxoplasmosis, these two compounds and HDQ reduced the percentages of infected peritoneal cells and decreased the parasite loads in lungs and livers. Compound B showed a tendency toward lowering parasite loads in brains in a mouse model of toxoplasmic encephalitis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01001-09

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