Effects of Age and Sex on Single-Dose Pharmacokinetics of Tigecycline in Healthy Subjects-Reference-Cited by-同舟云学术

Effects of Age and Sex on Single-Dose Pharmacokinetics of Tigecycline in Healthy Subjects

Published:2005-04 Issue:4 Volume:49 Page:1656-1659
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Muralidharan Gopal¹,Fruncillo Richard J.²,Micalizzi Marlynne¹,Raible Donald G.¹,Troy Steven M.¹

Affiliation:

1. Wyeth Research, Collegeville

2. Wyeth Research Clinical Pharmacology Unit, Philadelphia, Pennsylvania

Abstract

ABSTRACT The pharmacokinetics of tigecycline was evaluated in 46 healthy young and elderly men and women. Except for the volumes of distribution at steady state (approximately 350 liters in women versus 500 liters in men), there were no significant differences in tigecycline pharmacokinetic parameters. Based on pharmacokinetics, no dosage adjustment is warranted based on age or sex.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.4.1656-1659.2005

Reference26 articles.

1. In Vitro Activities of Tigecycline against Erythromycin-Resistant Streptococcus pyogenes and Streptococcus agalactiae : Mechanisms of Macrolide and Tetracycline Resistance

2. In Vitro Activities of Tigecycline (GAR-936) against Recently Isolated Clinical Bacteria in Spain

3. Biedenbach, D. J., M. L. Beach, and R. N. Jones. 2001. In vitro antimicrobial activity of GAR-936 tested against antibiotic-resistant gram-positive blood stream infection isolates and strains producing extended-spectrum beta-lactamases. Diagn. Microbiol. Infect. Dis.40:173-177.

4. Cazzola, M., F. Blasi, S. Centanni, C. F. Donner, and L. Allegra. 2001. Advances in the research and development of chemotherapeutic agents for respiratory tract bacterial infections. Pulm. Pharmacol. Ther.14:367-381.

5. Chopra, I. 2002. New developments in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors. Drug Resist. Updates5:119-125.

Cited by 53 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pharmacokinetics of Antibacterial Agents in the Elderly: The Body of Evidence;Biomedicines;2023-06-04

2. Population Pharmacokinetics of Tigecycline: A Systematic Review;Drug Design, Development and Therapy;2022-06

3. Therapeutic Drug Monitoring of Antibiotics in the Elderly: A Narrative Review;Therapeutic Drug Monitoring;2022-02

4. Evaluation of in vitro activity of tigecycline against multidrug-resistant clinical isolates;APIK Journal of Internal Medicine;2022

5. Tetracyclines;Reference Module in Biomedical Sciences;2021