In Vitro Effects of Spectinomycin and Ceftriaxone Alone or in Combination with Other Antibiotics against Chlamydia trachomatis

Author:

Shang Shuxian1,Xia Longqing1,Zhong Mingying1,Zhang Jinping1,Zhao Jianbin1,Gong Xiangdong1,Mabey David2,Wang Qianqiu1

Affiliation:

1. National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China

2. Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, England

Abstract

ABSTRACT The in vitro effects of spectinomycin and ceftriaxone, alone or in combination with erythromycin, ofloxacin, and doxycycline, against Chlamydia trachomatis were investigated by the checkerboard method and compared by Ridit (reference identical unit) analysis. A combination of spectinomycin with erythromycin or doxycycline was found to be more effective than that of ceftriaxone.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference23 articles.

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5. Centers for Disease Control and Prevention. 1993. Sexually transmitted diseases treatment guidelines. Morb. Mortal. Wkly. Rep.42(RR-14):1-102.

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