Imidazo[1,2- a ]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection In Vivo-Reference-Cited by-同舟云学术

Imidazo[1,2- a ]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection In Vivo

Published:2016-08 Issue:8 Volume:60 Page:5018-5022
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Moraski Garrett C.¹,Cheng Yong²,Cho Sanghyun³,Cramer Jeffrey W.⁴,Godfrey Alexander⁵,Masquelin Thierry⁵,Franzblau Scott G.³,Miller Marvin J.⁶,Schorey Jeffery²

Affiliation:

1. Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana, USA

2. Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA

3. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA

4. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA

5. Discovery Chemistry, Eli Lilly and Company, Indianapolis, Indiana, USA

6. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA

Abstract

ABSTRACT A panel of six imidazo[1,2- a ]pyridine-3-carboxamides (IAPs) were shown to have low-micromolar activity against Mycobacterium avium strains. Compound ND-10885 (compound 2) showed significant activity in the lung, spleen, and liver in a mouse M. avium infection model. A combined regimen consisting of ND-10885 (compound 2) and rifampin was additive in its anti- M. avium activity in the lung. Our data indicate that IAPs represent a new class of antibiotics that are active against M. avium and could potentially serve as an effective addition to a combined treatment regimen.

Funder

Hsiri Therapeutics

HHS | NIH | NIH Office of the Director

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00618-16

Reference18 articles.

1. The epidemiology of nontuberculous mycobacterial diseases in the United States. Results from a national survey;O'Brien RJ;Am Rev Respir Dis,1987

2. Prevalence of Nontuberculous Mycobacterial Lung Disease in U.S. Medicare Beneficiaries