New TEM-Derived Extended-Spectrum β-Lactamase and Its Genomic Context in Plasmids from Salmonella enterica Serovar Derby Isolates from Uruguay-Reference-Cited by-同舟云学术

New TEM-Derived Extended-Spectrum β-Lactamase and Its Genomic Context in Plasmids from Salmonella enterica Serovar Derby Isolates from Uruguay

Published:2006-02 Issue:2 Volume:50 Page:781-784
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Vignoli Rafael¹,Cordeiro Nicolas F.¹,García Virginia¹,Mota María Inés¹,Betancor Laura²,Power Pablo³,Chabalgoity José A.²,Schelotto Felipe¹,Gutkind Gabriel³,Ayala Juan A.⁴

Affiliation:

1. Departamento de Bacteriología y Virología

2. Departamento de Biotecnología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, 11600 Montevideo, Uruguay

3. Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina

4. Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Campus de Cantoblanco, 28049 Madrid, Spain

Abstract

ABSTRACT A small (8.2-kb) ColE1 plasmid encoding TEM-144 (a new β-lactamase with a ceftazidimase profile) was sequenced by a gene-walking strategy. The bla TEM allele was carried on a Tn 2 element, disrupting a Rom protein gene. TEM-144 differs from TEM-1 by two mutations (R164C and E240K) and from the ceftazidime-hydrolyzing TEM-91 by one mutation (T182M).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.50.2.781-784.2006

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