In Vitro Uptake of Isometamidium and Diminazene by Trypanosoma brucei-Reference-Cited by-同舟云学术

In Vitro Uptake of Isometamidium and Diminazene by Trypanosoma brucei

Published:1974-09 Issue:3 Volume:6 Page:372-374
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Girgis-Takla Pamela¹²,James Dinah M.¹²

Affiliation:

1. Department of Pharmaceutical Chemistry, University of Ife, University of Ibadan, Nigeria

2. Department of Pharmacology, University of Ibadan, Nigeria

Abstract

The cattle trypanocide, isometamidium, was readily taken up by inactivated Trypanosoma brucei , while its uptake by living parasites was reduced or inhibited by plasma. In both respects isometamidium differs from diminazene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.6.3.372

Reference8 articles.

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4. Studies on isometamidium. Deposits of isometamidium in rats and mice and their importance for prophylaxis against Trypanosoma congolense;Hill J.;Trans. Roy. Soc. Trop. Med. Hyg.,1963

5. Separation of trypanosomes from the blood of infected rats and mice by anion-exchangers;Lanham S. M.;Nature (London),1968

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1. Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake;International Journal for Parasitology: Drugs and Drug Resistance;2013-12

2. Drugs and drug resistance in African trypanosomiasis;Drug Resistance Updates;2007-02

3. SSCP analysis of the P2 purine transporter TcoAT1 gene of Trypanosoma congolense leads to a simple PCR-RFLP test allowing the rapid identification of diminazene resistant stocks;Acta Tropica;2006-11

4. Pharmacology of existing drugs for animal trypanosomiasis;Acta Tropica;1993-09

5. The pharmacology of isometamidium;Journal of Veterinary Pharmacology and Therapeutics;1988-09