Affiliation:
1. Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
Abstract
Alphaviruses include important human pathogens such as Chikungunya and the encephalitic alphaviruses. There are currently no licensed alphavirus vaccines or effective antiviral therapies, and more molecular information on virus particle structure and function is needed. Here, we highlight the important role of the E2 juxtamembrane D-loop in mediating virus budding and particle production. Our results demonstrated that this E2 region affects both the formation of the external glycoprotein lattice and its interactions with the internal capsid protein shell.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases
HHS | NIH | National Institute of General Medical Sciences
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference37 articles.
1. Kuhn RJ. 2013. Togaviridae, p 629–650. In Knipe DM, Howley PM (ed), Fields virology, 6th ed. Lippincott/Williams & Wilkins, Philadelphia, PA.
2. Griffin DE. 2013. Alphaviruses, p 651–686. In Knipe DM, Howley PM (ed), Fields virology, 6th ed. Lippincott/Williams & Wilkins, Philadelphia, PA.
3. Mapping the Structure and Function of the E1 and E2 Glycoproteins in Alphaviruses
4. The Alphavirus Exit Pathway: What We Know and What We Wish We Knew
5. Identification of a protein binding site on the surface of the alphavirus nucleocapsid and its implication in virus assembly
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