Prospective randomized double-blind comparison of nephrotoxicity and auditory toxicity of tobramycin and netilmicin-Reference-Cited by-同舟云学术

Prospective randomized double-blind comparison of nephrotoxicity and auditory toxicity of tobramycin and netilmicin

Published:1984-11 Issue:5 Volume:26 Page:766-769
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gatell J M,SanMiguel J G,Araujo V,Zamora L,Maña J,Ferrer M,Bonet M,Bohe M,Jimenez de Anta M T

Abstract

Netilmicin or tobramycin was administered to 197 patients in a prospective randomized double-blind trial. Of these patients, 140 recipients of nine or more doses of netilmicin or tobramycin could be evaluated for nephrotoxicity. Fifty-five patients were able to cooperate in the administration of serial audiograms. Nephrotoxicity of similar severity developed in 7 of 73 (9.6%) recipients of tobramycin and in 7 of 67 (10.4%) recipients of netilmicin (P greater than 0.05). Mild or slight auditory toxicity developed in 5 of 28 (17.8%) recipients of tobramycin and in 2 of 27 (7.4%) recipients of netilmicin (P greater than 0.05).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.26.5.766

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