Abstract
The effects of antibiotic combinations against Pseudomonas aeruginosa infections frequently found in hospitalized patients were investigated. By means of an agar plate dilution checkerboard method, combinations of piperacillin-fosfomycin, cefoperazone-fosfomycin, and cefsulodin-fosfomycin were synergistic against 80.0, 85.0, and 82.6% of the strains tested. The mean fractional inhibitory concentration indices of piperacillin-fosfomycin, cefoperazone-fosfomycin, and cefsulodin-fosfomycin were 0.48, 0.42, and 0.46, respectively. The synergistic activities of these combinations were enhanced by the addition of a small amount of tobramycin, 0.25 micrograms/ml.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference16 articles.
1. Studies on combination of antibiotics (IV). In vitro combined effect of fosfomycin and dibekacin against clinical isolates;Aonuma A.;Chemotherapy,1982
2. Barry A. L. 1980. Procedure for testing antibiotics in agar media: theoretical considerations p. 1-23. In V. Lorian (ed.) Antibiotics in laboratory medicine. The Williams & Wilkins Co. Baltimore.
3. A method for testing for synergy with any number of agents;Berenbaum M. C.;J. Infect. Dis.,1978
4. Antagonists of nucleic acid derivatives. VIII. Synergism in combination of biochemically related antimetabolites;Elion G. B.;J. Biol. Chem.,1954
5. Comparative in vitro activities of 3-lactamtobramycin combinations against Pseudomonas aeruginosa and multidrug-resistant gram-negative enteric bacilli;Fass R. J.;Antimicrob. Agents Chemother.,1982
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