In Vitro , In Vivo , and Absorption, Distribution, Metabolism, and Excretion Evaluation of SF 5 -Containing N,N’ -Diarylureas as Antischistosomal Agents-Reference-Cited by-同舟云学术

In Vitro , In Vivo , and Absorption, Distribution, Metabolism, and Excretion Evaluation of SF 5 -Containing N,N’ -Diarylureas as Antischistosomal Agents

Published:2021-09-17 Issue:10 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Probst Alexandra¹²^ORCID,Pujol Eugènia³^ORCID,Häberli Cécile¹²,Keiser Jennifer¹²^ORCID,Vázquez Santiago³^ORCID

Affiliation:

1. Swiss Tropical and Public Health Institute, Basel, Switzerland

2. University of Basel, Basel, Switzerland

3. Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia i Ciències de l’Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Barcelona, Spain

Abstract

In recent years, N,N’ -diarylureas have emerged as a promising chemotype for the treatment of schistosomiasis, a parasite-caused disease that poses a considerable health burden to millions of people worldwide. Here, we report a novel series of N,N’ -diarylureas featuring the scarcely explored pentafluorosulfanyl group (SF 5 ).

Funder

Swiss National Science Foundation

Institut de Biomedicina de la Universitat de Barcelona

Fundació la Marató de TV3

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00615-21

Reference40 articles.

1. Schistosomiasis