Cardif-Mediated Signaling Controls the Initial Innate Response to Dengue Virus In Vivo-Reference-Cited by-同舟云学术

Cardif-Mediated Signaling Controls the Initial Innate Response to Dengue Virus In Vivo

Published:2009-08-15 Issue:16 Volume:83 Page:8276-8281
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Perry Stuart T.¹,Prestwood Tyler R.¹,Lada Steven M.¹,Benedict Chris A.²,Shresta Sujan¹

Affiliation:

1. Division of Vaccine Discovery

2. Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037

Abstract

ABSTRACT The role of Cardif-dependent signaling in controlling dengue virus (DENV) infection and regulating type I interferon (IFN) production in vivo was examined in Cardif-deficient mice. DENV RNA levels were significantly elevated in both the serum and lymphoid tissues of Cardif −/− mice at early times compared to those in wild-type animals. Type I IFN production was delayed in these locales of Cardif −/− mice until 18 h postinfection, indicating that Cardif regulates the initial type I IFN response in lymphoid tissues. In contrast, DENV viral loads in nonlymphoid tissues were similar between Cardif −/− and wild-type mice. These results reveal that RNA helicase-mediated sensing acts as a first line of innate defense against DENV infection in vivo and functions in a tissue-dependent manner.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00365-09

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