Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival-Reference-Cited by-同舟云学术

Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Liang Jin Hua¹²³⁴,Wang Chong¹,Yiu Stephanie Pei Tung¹²³⁵,Zhao Bo¹^ORCID,Guo Rui¹²³,Gewurz Benjamin E.¹²³⁵^ORCID

Affiliation:

1. Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

2. Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA

3. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA

4. Department of Hematology, First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

5. Graduate Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA

Abstract

Epstein-Barr virus (EBV) is associated with 200,000 cancers annually, including B-cell lymphomas in immunosuppressed hosts. Hypomorphic mutations of the de novo pyrimidine synthesis pathway enzyme cytidine 5′ triphosphate synthase 1 (CTPS1) suppress cell-mediated immunity, resulting in fulminant EBV infection and EBV + central nervous system (CNS) lymphomas.

Funder

NIH

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01530-21

Reference56 articles.

1. Epstein–Barr Virus and Cancer

2. Herpesvirus Epigenetic Reprogramming and Oncogenesis

3. Recent molecular and therapeutic advances in B-cell non-Hodgkin lymphoma in children