An Alternative Splicing Variant of the Mixed-Lineage Leukemia 5 Protein Is a Cellular Adhesion Receptor for ScaA of Orientia tsutsugamushi

Author:

Nguyen Yen Thi Hai123,Kim Chaewon12,Kim Hong-Il12,Kim Yuri13,Lee Sang-Eun24,Chang Sunghoe24,Ha Na-Young5,Cho Nam-Hyuk12367ORCID

Affiliation:

1. Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea

2. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea

3. Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul, Republic of Korea

4. Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea

5. Biomedical Research Institute, Chungnam National University Hospital, Daejeon, Republic of Korea

6. Seoul National University Bundang Hospital, Seongnam, Republic of Korea

7. Wide River Institute of Immunology, Seoul National University, Hongcheon, Republic of Korea

Abstract

O. tsutsugamushi is a mite-borne pathogen that causes scrub typhus. As an obligately intracellular pathogen, its adhesion to and invasion of host cells are critical steps for bacterial growth.

Funder

MOHW | Korea Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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