RISC in Entamoeba histolytica: Identification of a Protein-Protein Interaction Network for the RNA Interference Pathway in a Deep-Branching Eukaryote-Reference-Cited by-同舟云学术

RISC in Entamoeba histolytica: Identification of a Protein-Protein Interaction Network for the RNA Interference Pathway in a Deep-Branching Eukaryote

Published:2021-10-26 Issue:5 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhang Hanbang¹,Veira Juliana¹,Bauer Sarah Twitty¹,Yip Christopher¹,Singh Upinder¹²^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Internal Medicine, Stanford University School of Medicine, Stanford, California, USA

2. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA

Abstract

Entamoeba histolytica is a leading parasitic cause of death in developing countries, and our efforts are focused on defining the molecular basis of RNA interference (RNAi) gene regulation in this parasite. The Entamoeba RNAi pathway effectively silences a subset of endogenous genes and has also been harnessed as a gene silencing tool to study gene function in this organism.

Funder

Foundation for the National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01540-21

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