Gcn5p and Ubp8p Affect Protein Ubiquitylation and Cell Proliferation by Altering the Fermentative/Respiratory Flux Balance in Saccharomyces cerevisiae-Reference-Cited by-同舟云学术

Gcn5p and Ubp8p Affect Protein Ubiquitylation and Cell Proliferation by Altering the Fermentative/Respiratory Flux Balance in Saccharomyces cerevisiae

Published:2020-08-25 Issue:4 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

De Palma Antonella¹,Fanelli Giulia²³,Cretella Elisabetta²³,De Luca Veronica²,Palladino Raffaele Antonio²,Panzeri Valentina¹,Roffia Valentina¹,Saliola Michele³,Mauri Pierluigi¹⁴^ORCID,Filetici Patrizia²

Affiliation:

1. Proteomics and Metabolomics Unit, Institute for Biomedical Technologies (ITB-CNR), Segrate, Italy

2. Institute of Molecular Biology and Pathology/CNR, Sapienza University of Rome, Rome, Italy

3. Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy

4. Institute of Life Sciences, School of Advanced Studies Sant’Anna, Pisa, Italy

Abstract

We propose a study showing a novel role of Gcn5p and Ubp8p in the process of ubiquitylation of the yeast proteome which includes main glycolytic enzymes. Interestingly, in the absence of Gcn5p and Ubp8p glucose consumption and redox balance were altered in yeast. We believe that these results and the role of Gcn5p and Ubp8p in sugar metabolism might open new perspectives of research leading to novel protocols for counteracting the enhanced glycolysis in tumors.

Funder

Regione Lazio

Consiglio Nazionale delle Ricerche

icare

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01504-20

Reference44 articles.

1. Yeast: An Experimental Organism for 21st Century Biology