Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury-Reference-Cited by-同舟云学术

Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Sims Amy C.¹^ORCID,Mitchell Hugh D.²,Gralinski Lisa E.¹,Kyle Jennifer E.²,Burnum-Johnson Kristin E.²^ORCID,Lam Mariam³,Fulcher M. Leslie³,West Ande¹,Smith Richard D.²,Randell Scott H.³⁴,Metz Thomas O.²^ORCID,Sheahan Timothy P.¹,Waters Katrina M.²,Baric Ralph S.¹^ORCID

Affiliation:

1. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. Biological Sciences Division, Pacific Northwest National Laboratories, Richland, Washington, USA

3. Marsico Lung Institute Tissue Procurement and Cell Culture Core, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

4. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe atypical pneumonia in infected individuals, but the underlying mechanisms of pathogenesis remain unknown. While much has been learned from the few reported autopsy cases, an in-depth understanding of the cells targeted by MERS-CoV in the human lung and their relative contribution to disease outcomes is needed.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Cystic Fibrosis Foundation

DOE | NNSA | LDRD | Pacific Northwest National Laboratory

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01572-21

Reference86 articles.

1. A decade after SARS: strategies for controlling emerging coronaviruses