Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse-Reference-Cited by-同舟云学术

Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rudzki Elizabeth N.¹,Ander Stephanie E.¹²,Coombs Rachel S.¹^ORCID,Alrubaye Hisham S.¹,Cabo Leah F.¹,Blank Matthew L.¹,Gutiérrez-Melo Nicolás¹,Dubey J. P.³,Coyne Carolyn B.⁴^ORCID,Boyle Jon P.¹^ORCID

Affiliation:

1. Department of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

3. Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland, USA

4. Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA

Abstract

Toxoplasma gondii is a globally ubiquitous pathogen that can cause severe disease in HIV/AIDS patients and can also cross the placenta and infect the developing fetus. We have found that placental and immune cells infected with T. gondii secrete significant amounts of a chemokine (called CCL22) that is critical for immune tolerance during pregnancy.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01591-21

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