Mutations in Ribosomal Protein L3 Are Associated with Oxazolidinone Resistance in Staphylococci of Clinical Origin-Reference-Cited by-同舟云学术

Mutations in Ribosomal Protein L3 Are Associated with Oxazolidinone Resistance in Staphylococci of Clinical Origin

Published:2009-12 Issue:12 Volume:53 Page:5275-5278
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Locke Jeffrey B.¹,Hilgers Mark¹,Shaw Karen Joy¹

Affiliation:

1. Trius Therapeutics, Inc., 6310 Nancy Ridge Drive, Suite 105, San Diego, California 92121

Abstract

ABSTRACT Following recent reports of ribosomal protein L3 mutations in laboratory-derived linezolid-resistant (LZD r ) Staphylococcus aureus , we investigated whether similar mutations were present in LZD r staphylococci of clinical origin. Sequence analysis of a variety of LZD r isolates revealed two L3 mutations, ΔSer145 ( S. aureus NRS127) and Ala157Arg ( Staphylococcus epidermidis 1653059), both occurring proximal to the oxazolidinone binding site in the peptidyl transferase center. The oxazolidinone torezolid maintained a ≥8-fold potency advantage over linezolid for both strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01032-09

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