Affiliation:
1. Department of Medicine, University of Alabama, Birmingham 35294.
Abstract
Blood mononuclear cells from 47 cats experimentally infected with feline immunodeficiency virus (FIV) were examined by using monoclonal antibodies directed against feline CD4 and CD8 homologs, a pan-T-cell antigen, and cell surface immunoglobulin. Significant inversion of the CD4+/CD8+ T-cell ratio was observed only in cats that were infected for 18 months or more. This inversion was associated with a decrease in the absolute numbers of CD4+ T cells and a concomitant increase in CD8+ cells. However, the total numbers of circulating T and B cells were not significantly reduced. Cats infected with FIV for 24 to 28 months also had significantly elevated levels of serum immunoglobulin G (IgG), but normal levels of IgA and IgM. The long-term decline in CD4+ T cells and hypergammaglobulinemia observed in FIV-infected cats resemble the abnormalities occurring in humans after human immunodeficiency virus infection.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference21 articles.
1. Feline homologue the CD4 antigen and a pan-T cell marker;Ackley C. D.;Fed. Proc.,1989
2. Identification of a CD4 homologue in the cat;Ackley C. D.;Tissue Antigens,1990
3. HIV-1 specific B cell activation. A major constituent of spontaneous B cell activation during HIV-1 infection;Amadori A.;J. Immunol.,1989
4. B-cell immunodeficiency in acquired immune deficiency syndrome;Ammann A. J.;Immunodeficiency,1984
5. Chicken thymocyte specific antigen identified by monoclonal antibodies: ontogeny, tissue distributions, and biochemical characterization;Chen C. H.;Eur. J. Immunol.,1984
Cited by
266 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献