Type 3 Immunity during Clostridioides difficile Infection: Too Much of a Good Thing?

Abstract

Clostridioides (formerly known as Clostridium ) difficile is the leading cause of hospital-acquired gastrointestinal infections in the United States and one of three urgent health care threats identified by the Centers for Disease Control and Prevention. C. difficile disease is mediated by the production of toxins that disrupt the epithelial barrier and cause a robust host inflammatory response.