The Psoriasis Risk Allele HLA-C*06:02 Shows Evidence of Association with Chronic or Recurrent Streptococcal Tonsillitis

Author:

Haapasalo Karita12,Koskinen Lotta L. E.13,Suvilehto Jari4,Jousilahti Pekka5,Wolin Annika5,Suomela Sari6,Trembath Richard7,Barker Jonathan8,Vuopio Jaana910,Kere Juha71112,Jokiranta T. Sakari12,Saavalainen Päivi13

Affiliation:

1. Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland

2. Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland

3. Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland

4. Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland

5. Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland

6. Department of Dermatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

7. School of Basic and Medical Biosciences, Faculty of Medicine and Life Sciences, Kings College, London, United Kingdom

8. St. John's Institute of Dermatology, Faculty of Life Sciences and Medicine, Kings College, London, United Kingdom

9. Medical Microbiology and Immunology, University of Turku, Turku, Finland

10. Bacterial Infections Unit, National Institute for Health and Welfare, Helsinki, Finland

11. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden

12. Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland

Abstract

Pharyngeal tonsillitis is one of the most common upper respiratory tract infections, and group A streptococcus is the most important bacterial pathogen causing it. While most patients experience tonsillitis only rarely, a subset of patients suffers from recurrent or chronic tonsillitis or pharyngitis.

Funder

Suomen Kulttuurirahasto

Academy of Finland

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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