Abstract
Previous studies have noted that the prevalence of certain gonococcal colony types is influenced by the physiological state of the human host. Consequently eight different gonococcal strains were passed on clear typing medium, and opaque (Op) and transparent (Tr) variants of heavily pilated (P++) bacteria were selected. P++Op and P++Tr were injected into 11-day-old chicken embryos, and the resulting mortality was determined. In every case the Tr variants were more lethal to the embryos than were the Op variants (P = 0.01). P++Tr were stable in vivo, but chicken embryos injected with P++Op strains developed bacteremia with P++Tr organisms. However, chicken blood was not bactericidal for either colonial variant. These results indicate that transparent pilated bacteria may be more virulent than opaque pilated bacteria and that in vivo selection of transparent forms occurs.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference24 articles.
1. Braun W. 1966. Representative types of mutants. III. Mutations affecting colonial morphology p. 153-163. In Bacterial genetics. The W. B. Saunders Co. Philadelphia.
2. Gonococcal colony types;Brown W. J.;J. Am. Med. Assoc.,1974
3. Studies of gonococcus infection. III. Correlation of gonococcal colony morphology with infectivity for the chick embryo;Buchanan T. M.;J. Exp. Med.,1973
4. Experimental meningococcus infection of the chick embryo;Buddingh G. J.;J. Exp. Med.,1939
5. Pathogenesis and immunology of experimental gonococcal infection: virulence of colony types of Neisseria gonorrhoeae for chicken embryos;Bumgarner L;Infect. Immun.,1973
Cited by
30 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献