Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of anmgrBDeletion Mutant-Reference-Cited by-同舟云学术

Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of anmgrBDeletion Mutant

Published:2015-07-22 Issue:10 Volume:53 Page:3341-3344
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J. Clin. Microbiol.

Author:

Giani Tommaso,Arena Fabio,Vaggelli Guendalina,Conte Viola,Chiarelli Adriana,Henrici De Angelis Lucia,Fornaini Rossella,Grazzini Maddalena,Niccolini Fabrizio,Pecile Patrizia,Rossolini Gian Maria

Abstract

We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistantKlebsiella pneumoniaecarbapenemase (KPC)-producingK. pneumoniaeisolates which was mirrored by increased colistin consumption. The outbreak was mostly traced to the clonal expansion of anmgrBdeletion mutant of an ST512 strain that produced KPC-3.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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