Calprotectin-Mediated Zinc Chelation Inhibits Pseudomonas aeruginosa Protease Activity in Cystic Fibrosis Sputum-Reference-Cited by-同舟云学术

Calprotectin-Mediated Zinc Chelation Inhibits Pseudomonas aeruginosa Protease Activity in Cystic Fibrosis Sputum

Published:2021-06-08 Issue:13 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Vermilyea Danielle M.¹,Crocker Alex W.¹,Gifford Alex H.²³,Hogan Deborah A.¹^ORCID

Affiliation:

1. Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

2. Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA

3. The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire, USA

Abstract

The factors that contribute to worse outcomes in individuals with cystic fibrosis (CF) with chronic Pseudomonas aeruginosa infections are not well understood. Therefore, there is a need to understand environmental factors within the CF airway that contribute to P. aeruginosa colonization and infection.

Funder

Cystic Fibrosis Foundation

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of Environmental Health Sciences

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00100-21

Reference84 articles.