Affiliation:
1. INSERM U853, F33076 Bordeaux, France, and Université Victor Segalen Bordeaux 2, Laboratoire de Bactériologie, F33076 Bordeaux, France
Abstract
SUMMARY
The discovery of
Helicobacter pylori
in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent,
H. pylori
, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of
H. pylori
infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology
Reference602 articles.
1. Abdalla, A. M., E. M. Sordillo, Z. Hanzely, G. I. Perez Perez, M. J. Blaser, P. R. Holt, and S. F. Moss. 1998. Insensitivity of the CLOtest for H. pylori, especially in the elderly. Gastroenterology115:243-244.
2. Adachi, K., A. Kawamura, M. Ono, K. Masuzaki, T. Takashima, M. Yuki, H. Fujishiro, S. Ishihara, and Y. Kinoshita. 2002. Comparative evaluation of urine-based and other minimally invasive methods for the diagnosis of Helicobacter pylori infection. J. Gastroenterol.37:703-708.
3. Agha, A., A. R. Opekun, S. Abudayyeh, and D. Y. Graham. 2005. Effect of different organic acids (citric, malic and ascorbic) on intragastric urease activity. Aliment. Pharmacol. Ther.21:1145-1148.
4. Agha-Amiri, K., U. Peitz, D. Mainz, S. Kahl, A. Leodolter, and P. Malfertheiner. 2001. A novel immunoassay based on monoclonal antibodies for the detection of Helicobacter pylori antigens in human stool. Z. Gastroenterol.39:555-560.
5. PCR Using 3′-Mismatched Primers To Detect A2142C Mutation in 23S rRNA Conferring Resistance to Clarithromycin in
Helicobacter pylori
Clinical Isolates
Cited by
539 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献