Antibody Biomarkers Associated with Sterile Protection Induced by Controlled Human Malaria Infection under Chloroquine Prophylaxis

Author:

Obiero Joshua M.1ORCID,Campo Joseph J.2,Scholzen Anja3,Randall Arlo2,Bijker Else M.3,Roestenberg Meta3,Hermsen Cornelus C.3,Teng Andy2,Jain Aarti1,Davies D. Huw1,Sauerwein Robert W.3,Felgner Philip L.1

Affiliation:

1. Vaccine Research and Development Center, Department of Physiology and Biophysics, University of California, Irvine, Irvine, California, USA

2. Antigen Discovery, Inc., Irvine, California, USA

3. Radboud University Medical Center, Department of Medical Microbiology, Nijmegen, The Netherlands

Abstract

Infection by Plasmodium parasites has been a major cause of mortality and morbidity in humans for thousands of years. Despite the considerable reduction of deaths, according to the WHO, over 5 billion people are still at risk, with about 216 million worldwide cases occurring in 2016. More compelling, 15 countries in sub-Saharan Africa bore 80% of the worldwide malaria burden. Complete eradication has been challenging, and the development of an affordable and effective vaccine will go a long way in achieving elimination. However, identifying vaccine candidate targets has been difficult. In the present study, we use a highly effective immunization protocol that confers long-lasting sterile immunity in combination with a whole P. falciparum proteome microarray to identify antibody responses associated with protection. This study characterizes a novel antibody profile associated with sterile protective immunity and trimodal humoral responses that sheds light on the possible mechanism of CPS-induced immunity against P. falciparum parasites.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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