Affiliation:
1. Research Laboratory, Linde Division, Union Carbide Corporation, Tonawanda, New York
2. E. J. Meyer Memorial Hospital, and School of Medicine, State University of New York at Buffalo, Buffalo, New York
Abstract
Gottlieb
, S. F. (Linde Division, Union Carbide Corporation, Tonawanda, N.Y.),
Noel R. Rose, Jerome Maurizi, and Edward H. Lanphier
. Oxygen inhibition of growth of
Mycobacterium tuberculosis
. J. Bacteriol.
87:
838–843. 1964.—Continuous or intermittent exposure to 3 atm of oxygen in the presence or absence of 40 mm of Hg CO
2
resulted in marked delay or inhibition of growth of
Mycobacterium tuberculosis
. This inhibition was more pronounced with newly inoculated cultures, as compared to young, actively growing cultures. Oxygen inhibition of growth was observed on both Lowenstein-Jensen and blood agar media. Bacteriostatic effects of oxygen are a direct function of exposure time. A more marked effect of oxygen was observed in the presence of isoniazid, streptomycin, or
p
-aminosalicyclic acid.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
22 articles.
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