Transformation of Morphine by Resting Cells and Cell-Free Systems of Arthrobacter Sp

Author:

Liras Paloma1,Umbreit W. W.1

Affiliation:

1. Department of Microbiology, Rutgers University, New Brunswick, New Jersey 08903

Abstract

Morphine can be transformed into 14-hydroxymorphine and a related unidentified material by resting cells of an Arthrobacter species. Cell-free extracts containing the transforming enzyme(s) have been obtained. O 2 , Fe 2+ , and reduced nicotinamide adenine dinucleotide stimulate the transformation.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference15 articles.

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3. Hydroxylation of trans-A'-tetrahydrocannabinol by hepatic microsomal oxygenase;Burstein S.;Ann. N. Y. Acad. Sci.,1971

4. Charney W. and H. L. Herzog. 1967. Microbial transformations of steroids. Academic Press Inc. New York.

5. Microbiological hydroxylation of certain indole alkaloids;Godtfredsen W. O.;Experientia,1958

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