Induction of hyperreactivity to endotoxin in mice by Coxiella burnetii-Reference-Cited by-同舟云学术

Induction of hyperreactivity to endotoxin in mice by Coxiella burnetii

Published:1984-09 Issue:3 Volume:45 Page:713-717
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Schramek S,Kazar J,Sekeyova Z,Freudenberg M A,Galanos C

Abstract

Intraperitoneal inoculation of mice with live or killed Coxiella burnetii phase I or phase II cells induced a marked hyperreactivity to the lethal effect of bacterial endotoxin and was accompanied by a marked hepatosplenomegaly. The degree and duration of hyperreactivity depended on the dose of C. burnetii administered and were higher with phase I than with phase II cells. Sensitization to the lethal effects of endotoxin and induction of splenomegaly by phase I C. burnetii cells also proceeded in the endotoxin-resistant C3H/HeJ strain of mice. Preincubation of C. burnetii cells with the corresponding immune serum significantly diminished the ability of phase I but not phase II cells to induce hyperreactivity to endotoxin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.45.3.713-717.1984

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