Involvement of Antibiotic Efflux Machinery in Glutathione-Mediated Decreased Ciprofloxacin Activity in Escherichia coli-Reference-Cited by-同舟云学术

Involvement of Antibiotic Efflux Machinery in Glutathione-Mediated Decreased Ciprofloxacin Activity in Escherichia coli

Published:2016-07 Issue:7 Volume:60 Page:4369-4374
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Goswami Manish¹²,Subramanian Mahesh³,Kumar Ranjeet²,Jass Jana²,Jawali Narendra¹

Affiliation:

1. Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

2. The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden

3. Bio-Organic Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

Abstract

ABSTRACT We have analyzed the contribution of different efflux components to glutathione-mediated abrogation of ciprofloxacin's activity in Escherichia coli and the underlying potential mechanism(s) behind this phenomenon. The results indicated that glutathione increased the total active efflux, thereby partially contributing to glutathione-mediated neutralization of ciprofloxacin's antibacterial action in E. coli . However, the role of glutathione-mediated increased efflux becomes evident in the absence of a functional TolC-AcrAB efflux pump.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00414-16

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