Reversal by Citrate of the Iodoacetate and Fluoride Inhibition of Glutamic Acid Production by Corynebacterium glutamicum

Author:

Birnbaum Jerome1,Demain Arnold L.1

Affiliation:

1. Fermentation Research Department, Merck & Co., Inc., Research Laboratories, Rahway, New Jersey 07065

Abstract

Citrate reversal of iodoacetate inhibition of glutamate synthesis is nonmetabolic. Reversal of fluoride inhibition is metabolic, occurring only at low Mg concentrations.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference4 articles.

1. Hewitt E. J. and D. J. D. Nicholas. 1963. Cations and anions: Inhibitions and interactions in metabolism and in enzyme activity p. 401. In R. M. Hochster and J. H. Quastel (ed.) Metabolic inhibitors vol. 2. Academic Press Inc. New York.

2. Fermentative production of glutamic acid and its application. X. Effects of antibiotics on the glutamic acid fermentation. Part III. Effect of penicillin and biotin;Matsuo T.;Amino Acids and Nucleic Acids,1966

3. The isolation and properties of phosphoglucomutase;Najjar V. A.;J. Biol. Chem.,1948

4. Precede d'obtention d'acid glutamique;Somerson N.;Belgian Patent,1961

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