Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions-Reference-Cited by-同舟云学术

Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions

Published:1989-09 Issue:9 Volume:63 Page:4085-4087
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lever A¹,Gottlinger H¹,Haseltine W¹,Sodroski J¹

Affiliation:

1. Laboratory of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Abstract

Sequences required for efficient packaging of human immunodeficiency virus type 1 (HIV-1) genome RNA into virus particles were identified. Deletion of 19 base pairs between the 5' long terminal repeat and the gag gene initiation codon of HIV-1 resulted in a virus markedly attenuated for replication in human T lymphocytes. The mutant virus was characterized by nearly wild-type ability to encode viral proteins and to produce virion particles. The mutant virions exhibited a significant reduction in the content of HIV-1-specific RNA. These results identify an important component of the HIV-1 packaging signal.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.63.9.4085-4087.1989

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