Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris-Reference-Cited by-同舟云学术

Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris

Published:2020-12-16 Issue:1 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bing Jian¹,Hu Tianren¹²³,Zheng Qiushi²³,Muñoz José F.⁴^ORCID,Cuomo Christina A.⁴^ORCID,Huang Guanghua¹^ORCID

Affiliation:

1. Department of Infectious Diseases, Huashan Hospital, and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China

2. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

3. University of Chinese Academy of Sciences, Beijing, China

4. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

Abstract

Candida auris is a newly emerging fungal pathogen of humans and has attracted considerable attention from both the clinical and basic research communities. Clinical isolates of C. auris are often resistant to one or more antifungal agents. To explore how antifungal resistance develops, we performed experimental evolution assays using a fluconazole-susceptible isolate of C. auris (BJCA001). After a series of passages through medium containing increasing concentrations of fluconazole, fungal cells acquired resistance.

Funder

National Science and Technology Major Project

NSFC | Foundation for Innovative Research Groups of the National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01466-20

Reference58 articles.

1. Candida auris: an Emerging Fungal Pathogen

2. Candida auris