Postantibiotic Effects and Bactericidal Activities of Levofloxacin and Gatifloxacin at Concentrations Simulating Those of Topical Ophthalmic Administration against Fluoroquinolone-Resistant and Fluoroquinolone-Sensitive Methicillin-Resistant Staphylococcus aureus Strains-Reference-Cited by-同舟云学术

Postantibiotic Effects and Bactericidal Activities of Levofloxacin and Gatifloxacin at Concentrations Simulating Those of Topical Ophthalmic Administration against Fluoroquinolone-Resistant and Fluoroquinolone-Sensitive Methicillin-Resistant Staphylococcus aureus Strains

Published:2008-08 Issue:8 Volume:52 Page:2970-2973
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hoshi Saichi¹²,Kikuchi Ken¹,Sasaki Takashi¹,Sotozono Chie²,Kinoshita Shigeru²,Hiramatsu Keiichi¹

Affiliation:

1. Department of Infection Control Science, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan

2. Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan

Abstract

ABSTRACT The bactericidal activities and postantibiotic effects (PAEs) of levofloxacin and gatifloxacin at concentrations corresponding to those in antibiotic eye drops against methicillin-resistant Staphylococcus aureus strains were determined. Levofloxacin and gatifloxacin at concentrations simulating those in eye drops showed lower bactericidal activities and shorter PAEs against fluoroquinolone-resistant strains than against fluoroquinolone-sensitive strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01466-07

Reference35 articles.

1. Shifting trends in bacterial keratitis in South Florida and emerging resistance to fluoroquinolones

2. Activity of Gatifloxacin in an In Vitro Pharmacokinetic-Pharmacodynamic Model against Staphylococcus aureus Strains either Susceptible to Ciprofloxacin or Exhibiting Various Levels and Mechanisms of Ciprofloxacin Resistance

3. Staphylococcal Cassette Chromosome mec (SCC mec ) Typing of Methicillin-Resistant Staphylococcus aureus Strains Isolated in 11 Asian Countries: a Proposal for a New Nomenclature for SCC mec Elements

4. Performance standards for antimicrobial susceptibility testing; 17th informational supplement. 2007

5. Craig, W. A., and S. Gudmundsson. 1996. Postantibiotic effect, p. 296-329. In V. Lorian (ed.), Antibiotics in laboratory medicine, 4th ed. The Williams & Wilkins Co., Baltimore, MD.

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antibacterial activity of a DNA topoisomerase I inhibitor versus fluoroquinolones in Streptococcus pneumoniae;PLOS ONE;2020-11-03

2. A hydrogel directly assembled from a copper metal–organic polyhedron for antimicrobial application;Chemical Communications;2019

3. Computational simulation and preparation of fluorescent magnetic molecularly imprinted silica nanospheres for ciprofloxacin or norfloxacin sensing;Journal of Separation Science;2014-11-17

4. Prospective Clinical Evaluation of 1.5% Levofloxacin Ophthalmic Solution in Ophthalmic Perioperative Disinfection;Journal of Ocular Pharmacology and Therapeutics;2013-12

5. Methicillin-Resistant Staphylococcus aureus and the Eye: Current Concepts and Management Strategies;Current Ophthalmology Reports;2013-10-30