Evaluation and comparison of two assays for detection of immunity to rubella infection

Author:

Brody J P,Binkley J H,Harding S A

Abstract

Two commercially available rapid screening tests, Rubacell (Abbott Laboratories; passive hemagglutination) and FIAX (International Diagnostic Technology; indirect immunofluorescence) were compared with a standard hemagglutination inhibition assay for detection of immunity to rubella infection. In tests of approximately 300 sera, both rapid assays were specific and sensitive and showed a high predictive value of a positive result. Within-run reproducibility studies were excellent for both tests; however, Rubacell was superior to FIAX with respect to time-cost analysis.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference10 articles.

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2. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera;Boyden S. V.;J. Exp. Med.,1951

3. Rubella antibodies in human serum: detection by the indirect fluorescent-antibody technique;Brown G. C.;Science,1964

4. Galen R. S. and S. R. Gambino. 1975. Beyond normality: the predictive value and efficiency of medical diagnosis p. 10-51. John Wiley and Sons Inc. New York.

5. Evaluation of an immunodiffusion test for screening of rubella immunity;Grandien M.;Acta Pathol. Microbiol. Scand. Sect. C,1976

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