Affiliation:
1. Department of Biochemistry, John Curtin School of Medical Research, The Institute of Advanced Studies, Australian National University, Canberra, A.C.T., Australia
Abstract
Mutants of
Escherichia coli
K-12 unable to synthesize the iron-sequestering compound, enterochelin, from 2,3-dihydroxybenzoate have been isolated and divided into three classes on the basis of tests for enzymatic complementation. The genes affected (designated
entD, entE
, and
entF
) have been mapped by cotransduction and are located at about minute 14 on the
E. coli
genome. They were found to be closely linked to other genes (
entA, entB
, and
entC
) concerned with enterochelin biosynthesis and a gene (
fep
) concerned with the uptake of the iron-enterochelin complex. No detectable diffusible intermediate in the formation of enterochelin from 2,3-dihydroxybenzoate was formed by cell extracts of mutants carrying mutations in the
entD, entE
, or
entF
genes.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
55 articles.
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