Abstract
Clavulanic acid and a penicillanic acid sulfone, when combined individually with piperacillin, synergistically inhibited various Enterobacteriaceae, Staphylococcus aureus, and Bacteroides fragilis. Clavulanic acid and piperacillin synergistically inhibited 91 of 170 (55%) isolates tested. Synergy was most often found against piperacillin-resistant bacteria: 65 of 69 isolates (94%). Although the penicillanic acid sulfone acted synergistically with piperacillin, inhibiting 62 of 170 strains (33%), the concentration of clavulanic acid required for synergy generally was less than that of penicillanic acid sulfone. Combination of piperacillin and cefotaxime, an inhibitor of type 1 beta-lactamases, rarely was synergistic and was antagonistic for several species. The combination of piperacillin with potent beta-lactamase inhibitors made piperacillin active against those isolates of Escherichia coli and Klebsiella and Bacteroides species, as well as selected other species, that are resistant to piperacillin by virtue of their production of beta-lactamases.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference9 articles.
1. Antagonism of the antibacterial action of some penicillins by other penicillins and cephalosporins;Acar J. F.;J. Clin. Invest.,1975
2. A sulfone,B-lactam compound which acts as a fl-lactamase inhibitor;Aswapokee N.;J. Antibiot.,1978
3. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins;Fu K. P.;Antimicrob. Agents Chemother.,1978
4. Beta-lactamase stability of HR 756, a novel cephalosporin, compared with that of cefuroxime and cefoxitin;Fu K. P.;Antimicrob. Agents Chemother.,1979
5. Comparative inhibition of ,6-lactamases by novel f8-lactam compounds;Fu K. P.;Antimicrob. Agents Chemother.,1979
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献