Author:
Udhayakumar V,Muthukkaruppan V R
Abstract
Outer membrane proteins (OMP) extracted from both smooth (C5) and rough (Rb2) strains of Salmonella typhimurium were able to induce protective immunity to salmonellosis. The OMP-induced protection lasted for at least 6 months. The antibody level was estimated by passive hemagglutination. In the C5 OMP-immunized mice, antibodies to both proteins and lipopolysaccharide were detected. On the other hand, in the Rb2 OMP-immunized mice, antiprotein but not antilipopolysaccharide antibodies were detected. Delayed-type hypersensitivity appeared as early as the second week after immunization with OMP and persisted through the fourth week.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference40 articles.
1. Comparative efficacy and toxicity of a ribosomal vaccine, acetone-killed cells, lipopolysaccharide, and a live cell vaccine prepared from Salmonella typhimurium;Angerman C. R.;Infect. Immun.,1978
2. Correlation of the duration and magnitude of protection against Salmonella infection afforded by various vaccines with antibody titers;Angerman C. R.;Infect. Immun.,1980
3. Ashcroft M. T. B. Singh C. C. Nicholson J. M. Ritchie E. Sobryan and F. Williams. 1967. A seven year field trial of two typhoid vaccines in Guyana. Lancet ii:1056-1059.
4. Cross-protection induced in mice by immunizations with proteins of related bacteria species;Barber C.;Zentralbl. Bakteriol. Hyg. I Abt. Orig. A,1976
5. Contributions a 1'etude des salmonellas. Proteines commune des salmonelles appartenant aux groupes B, C, D, et leur relation avec Citrobacter ballerup;Barber C.;Pathol. Microbiol.,1968
Cited by
83 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献