Cross-Protective Antigens of Group A Streptococci Types 3 and 31 and Types 46 and 51

Author:

Harrell William K.1,Ashworth Helen1,Davis Robert E.1

Affiliation:

1. Microbiological Reagents Unit, Center for Disease Control, Atlanta, Georgia 30333

Abstract

Reciprocal cross-protective antigens have been demonstrated between types 3 and 31 cocci, and one-way cross-protective antigens have been demonstrated between types 46 and 51 cocci. The reciprocal cross-protective antigen of types 3 and 31 is distinct from the specific M protein of either type. In the one-way cross relationship, type 46 cocci contain both type 46 and type 51 M proteins and therefore stimulate protective antibodies against both types. Type 51 cultures contain only the homologous M antigen. These relationships were demonstrated by capillary precipitin tests, indirect bactericidal tests, and in agar-gel diffusion patterns. The practical significance of these relationships in the serological typing of group A streptococci is discussed along with their possible role in immunity to streptococcal infections in man.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference13 articles.

1. New method of preparing immunizing antigens for the production of anti-M sera against certain serotypes of group A streptococci;Ashworth H.;J. Bacteriol.,1965

2. Antigenicity of the M protein of group A hemolytic streptocci. IV. Cross-reactivity between serotypes;Fox E. N.;J. Immunol.,1968

3. The precipitating antigen of Streptococcus pyogenes type 4;Hambly J. S.;J. Gen. Microbiol.,1958

4. The antigenic complex of Streptococcus haemolyticus. I. Demonstration of a type-specific substance in extracts of Streptococcus haemolyticus;Lancefield R. C.;J. Exp. Med.,1928

5. Lancefield R. C. 1955. Brochure of the Hospital of the Rockefeller Institute for Medical Research New York.

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