Production of Haemophilus influenzae b Meningitis in Infant Rats by Intraperitoneal Inoculation-Reference-Cited by-同舟云学术

Production of Haemophilus influenzae b Meningitis in Infant Rats by Intraperitoneal Inoculation

Published:1973-08 Issue:2 Volume:8 Page:278-290
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Smith Arnold L.¹²,Smith David H.¹²,Averill Damon R.¹²,Marino Joseph¹²,Moxon E. Richard¹²

Affiliation:

1. Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115

2. Department of Pediatrics, Harvard Medical School, and The Animal Research Center, Harvard School of Public Health Cambridge, Massachusetts 02115

Abstract

Sprague-Dawley rats have a marked age-related susceptibility to Haemophilus influenzae type b that does not correlate with serum bactericidal activity. Eighty percent of 5-day-old animals that survive to 48 h after an intraperitoneal inoculation of a mean lethal dose of bacteria have histologically documented meningitis. Animals surviving the inoculations as infants manifest cerebral dysfunction as adults. This model should facilitate experimental study of bacterial meningitis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.8.2.278-290.1973

Reference26 articles.

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4. Felton L. D. and P. Wegeforth. 1920. The production of experimental meningitis by direct inoculation into the subarachnoid space. Monogr. Rockefeller Inst. p. 5-25.

5. Experimental cerebrospinal meningitis in monkeys;Flexner S.;J. Exp. Med.,1907

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