Microbial Transformations of Natural Antitumor Agents: O -Demethylation of Vindoline by Sepedonium chrysospermum-Reference-Cited by-同舟云学术

Microbial Transformations of Natural Antitumor Agents: O -Demethylation of Vindoline by Sepedonium chrysospermum

Published:1978-10 Issue:4 Volume:14 Page:601-604
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wu Geng-Shuen¹,Nabih Thomas¹,Youel Leisa¹,Peczynska-Czoch Wanda¹,Rosazza John P.¹

Affiliation:

1. Division of Medicinal Chemistry and Natural Products, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242

Abstract

Vindoline ( 1a ) was transformed to O -demethylvindoline ( 1b ) by Sepedonium chrysospermum ATCC 13378 in 33% yield. Thin-layer and high-pressure liquid chromatographic methods distinguished 1b from previously reported microbial metabolites of vindoline. The structural proof of 1b was based on its mass spectral fragmentation pattern and on its chemical and nuclear magnetic resonance spectral properties.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.14.4.601

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1. Microbial Transformation of Some Bioactive Natural Products;Natural Product Letters;1998-10

2. Other Biotransformations;Biotransformations in Preparative Organic Chemistry;1989

3. Enzymic and chemical oxidations of leurosine to 5'-hydroxyleurosine;The Journal of Organic Chemistry;1987-04

4. Chapter 4 Metabolic Transformations of Alkaloids;The Alkaloids: Chemistry and Pharmacology;1986

5. Late enzymes of vindoline biosynthesis;Plant Cell Reports;1985-12