Streptococcus pneumoniae Elaborates Persistent and Prolonged Competent State during Pneumonia-Derived Sepsis

Author:

Lin Jingjun1,Park Pyunghun1,Li Hua1,Oh Myung Whan1,Dobrucki Iwona T.2,Dobrucki Wawrzyniec23,Lau Gee W.1

Affiliation:

1. Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

2. Molecular Imaging Laboratory, Beckman Institute For Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

3. Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Abstract

The competence regulon of pneumococcus regulates both genetic transformation and virulence. However, competence induction during host infection has not been examined. By using the serotype 2 strain D39, we transcriptionally fused the firefly luciferase ( luc ) to competence-specific genes and spatiotemporally monitored the competence development in a mouse model of pneumonia-derived sepsis. In contrast to the universally reported short transient burst of competent state in vitro , the naturally developed competent state was prolonged and persistent during pneumonia-derived sepsis.

Funder

HHS | National Institutes of Health

American Lung Association

UofI | UIC | Office of the Vice Chancellor for Research, University of Illinois at Chicago

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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