Affiliation:
1. Microbiology and Cell Biology Laboratory, Indian Institute of Science, Bangalore-560012, India
Abstract
Candida
spp. grown in synthetic medium supplemented with
l
-tryptophan as sole nitrogen source produced β-indoleethanol (β-IEA) and β-indolelactic acid (β-ILA). These compounds isolated from the culture filtrates were characterized by ultraviolet, infrared, and nuclear magnetic resonance spectral studies. Using
dl
-[
3
H]trypotophan in the medium, labeled β-IEA and β-ILA were isolated. Further, β-IEA was produced as a result incubating log-phase cells of
C. albicans
with β-ILA. Both β-IEA and β-ILA inhibited the growth of gram-positive and -negative bacteria. Autoantibiotic action of these compounds on
Candida
spp. and the reversal of this inhibition were studied.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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